Black soyabean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin
نویسندگان
چکیده
منابع مشابه
Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression
Small heterodimer partner (SHP) is a transcriptional corepressor regulating diverse metabolic processes. Here, we show that SHP acts as an intrinsic negative regulator of iron homeostasis. SHP-deficient mice maintained on a high-iron diet showed increased serum hepcidin levels, decreased expression of the iron exporter ferroportin as well as iron accumulation compared to WT mice. Conversely, ov...
متن کاملHepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts.
The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. We previously demonstrated that FPN1 was highly expressed in erythroblasts, a cell type that consumes most of the s...
متن کاملThe role of hepcidin in iron metabolism.
Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic...
متن کاملIron metabolism — a roleof hepcidin
Iron is the fourth most common element in the Earth’s crust and the most abundant transition metal in the human body. All living organisms have evolved sophisticated mechanisms to maintain appropriate iron levels in their cells and within their body. Maintaining the correct iron balance is crucial for health. Within the last few years, our understanding of iron metabolism has dramatically incre...
متن کاملInhibiting the hepcidin inhibitor for treatment of iron overload.
the expression of several homolog isoforms of UGTs in CLL patient samples and in the CLL cell line MEC-1, UGT2B17 mRNA expression was the only isoform expressed to any significant level. UGT2B17 mRNA expression was also shown to directly correlate with its enzymatic activity. Extending the biology further, UGT2B17 RNA silencing in the MEC-1 cell line was pursued followed by analysis of comparat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 2014
ISSN: 0007-1145,1475-2662
DOI: 10.1017/s0007114513004005